ROB FAIRLEY
When sampling the liver for histology (especially for cases with known liver disease) it is helpful to take multiple pieces and it is really helpful to make sure that what you select includes some decent-sized bile ductules. Facial eczema, for example, preferentially affects the larger ductules.
Some livers may have really badly affected areas (the end of the left lobe in facial eczema is a classic). You can sample the badly affected area but make sure you sample less affected areas as well, where the changes are often more diagnostic.